Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.50 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL25280176 | 1.00 | TBXAS1 (0.50) | TBXAS1SHMT2TSHRKDM4EALDH1A1 | |
| Succinic Acid SCHEMBL30449098 | 1.00 | TBXAS1 (0.50) | TBXAS1SHMT2TSHRKDM4EALDH1A1 | |
| Bicarbonate SCHEMBL5521423 | 0.87 | ALDH1A1 (0.41) | TBXAS1KDM4EALDH1A1GABRPGABRD | |
| Carbamic Acid SCHEMBL6394464 | 0.85 | CSNK1A1 (0.41) | TBXAS1KDM4EALDH1A1GABRPGABRD | |
| SCHEMBL5521428 | 0.80 | ALDH1A1 (0.37) | TBXAS1KDM4EALDH1A1CSNK1A1TYRO3 | |
| SCHEMBL168 | 0.80 | — | — | |
| SCHEMBL28949843 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1CSNK1A1TYRO3DYRK1B | |
| Trifluoroacetic Acid SCHEMBL3710003 | 0.78 | HRH4 (0.37) | TBXAS1KDM4EALDH1A1CSNK1A1TYRO3 | |
| Hydrochloric Acid SCHEMBL4445175 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL4023732 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116249693-A | Succinate salt of N- (3- (4- (3- (diisobutylamino) propyl) piperazin-1-yl) propyl) -1H-benzo [ d ] imidazol-2-amine, preparation and use thereof | 雅尔兹普罗泰特公司 | 2023-06-09 | — | — | CN | disclosed |