Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25826836 | 0.82 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL25826829 | 0.82 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL25826837 | 0.82 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL31304946 | 0.78 | ALDH1A1 (0.37) | ATMNPSR1ALDH1A1RAB9ANPC1 | |
| SCHEMBL23850108 | 0.75 | ALDH1A1 (0.38) | ATMNPSR1ALDH1A1RAB9ANPC1 | |
| SCHEMBL31465655 | 0.72 | NPSR1 (0.34) | NPSR1ALDH1A1 | |
| SCHEMBL23850381 | 0.70 | ROCK2 (0.44) | ATMNPSR1ALDH1A1RAB9ANPC1 | |
| SCHEMBL21835462 | 0.70 | SMN1; SMN2 (0.40) | ATMNPSR1ALDH1A1RAB9ANPC1 | |
| SCHEMBL15883822 | 0.70 | ALDH1A1 (0.35) | ATMALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL28918768 | 0.69 | NPC1 (0.38) | ATMNPSR1ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4460498-A1 | MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS | Blossomhill Therapeutics, Inc. (US) | 2024-11-13 | — | — | EP | disclosed |
| WO-2023133375-A1 | MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-07-13 | — | — | WO | disclosed |