SCHEMBL30450147

SCHEMBL30450147

CCCC(CCC)C(=O)O[Si](C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.46
HDAC2 Q92769 3/20 0.46
CHRM1 P11229 2/20 0.46
CHRM3 P20309 2/20 0.46
ADRA1A P35348 2/20 0.46
AKR1A1 P14550 1/20 0.46
HTR2A P28223 1/20 0.46
HTR2C P28335 1/20 0.46
HRH1 P35367 1/20 0.46
DRD3 P35462 1/20 0.46
SLC6A3 Q01959 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CYP3A4 P08684 2/20 0.44
TSHR P16473 2/20 0.44
NFKB1 P19838 2/20 0.44
NPSR1 Q6W5P4 2/20 0.44
HDAC7 Q8WUI4 3/20 0.42
HDAC8 Q9BY41 3/20 0.42
HDAC6 Q9UBN7 3/20 0.42
HDAC9 Q9UKV0 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9153817 0.82 HDAC1 (0.36) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL5962007 0.80 ALDH1A1 (0.39) TDP1CYP3A4TSHR
SCHEMBL6049286 0.79 CA2 (0.63) TDP1CYP3A4TSHRNPSR1SMN1; SMN2
SCHEMBL16540937 0.78 SLC1A2 (0.38) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL16540939 0.78 SLC1A2 (0.38) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL2448748 0.76 HDAC1 (0.58) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL358441 0.75 HDAC1 (0.55) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL10339951 0.75 HDAC1 (0.55) HDAC1HDAC2CHRM1CHRM3ADRA1A
SCHEMBL21611658 0.75 CA2 (0.40) CA1CA2SLC1A3SLC1A2SLC1A1
Ammonia Solution, Strong SCHEMBL7707573 0.74 HDAC1 (0.56) HDAC1HDAC2CHRM1CHRM3ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111712247-B sGC stimulators 塞科里昂医疗股份有限公司 2024-02-09 CN disclosed
CN-110267658-B Treatment of CNS disorders with sGC stimulators 帝善多制药公司 2024-02-02 CN disclosed
CN-117105939-A Fused bicyclic sGC stimulators 帝善多制药公司 2023-11-24 CN disclosed
CN-109790167-B SGC stimulators 塞科里昂医疗股份有限公司 2023-06-20 CN disclosed