Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | F12 | P00748 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.31 |
| ▸ | XDH | P47989 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24252383 | 1.00 | PLG (0.36) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL26771276 | 0.92 | PLG (0.31) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252263 | 0.77 | MAP4K4 (0.37) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252648 | 0.77 | PLG (0.31) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252292 | 0.76 | PLG (0.34) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252506 | 0.75 | MAP4K4 (0.37) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252659 | 0.75 | DHFR (0.31) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252733 | 0.74 | PLG (0.56) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL30451657 | 0.74 | PLG (0.56) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252663 | 0.74 | PLG (0.33) | PLGF12F11KLKB1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116947903-A | Inhibitors of complement factors and uses thereof | 安尼艾克松股份有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116261564-A | Inhibitors of complement factors and uses thereof | 安尼艾克松股份有限公司 | 2023-06-13 | — | — | CN | disclosed |
| EP-4185592-A1 | INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF | Annexon, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |