Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29016841 | 0.82 | PBRM1 (0.60) | TNKS2PBRM1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL19117678 | 0.73 | MKNK1 (0.49) | ALDH1A1KDM4EHSD17B10MAOAMAOB | |
| SCHEMBL30451265 | 0.71 | HTR2C (0.56) | TNKS2PBRM1ALDH1A1CYP1A2HPGD | |
| SCHEMBL21247061 | 0.70 | HSD17B10 (0.57) | TNKS2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL21261501 | 0.70 | CYP19A1 (0.46) | TNKS2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL34470617 | 0.69 | HTR2A (0.41) | ALDH1A1KDM4EHSD17B10MAOAMAOB | |
| SCHEMBL7536196 | 0.67 | KMT2A (0.40) | TNKS2PBRM1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL34471222 | 0.66 | HTR2A (0.32) | ALDH1A1KDM4EHSD17B10MAOAMAOB | |
| SCHEMBL14333949 | 0.65 | ALDH1A1 (0.41) | TNKS2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL21253039 | 0.65 | TNKS2 (0.44) | TNKS2PBRM1ALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261562-A | PI 3K-alpha inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-06-13 | — | — | CN | disclosed |