Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | PDK2 | Q15119 | 7/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20060875 | 1.00 | ALDH1A1 (0.51) | ALDH1A1PDK2HSP90AA1PDK4HSD17B10 | |
| SCHEMBL9653150 | 0.82 | ALDH1A1 (0.60) | ALDH1A1HPGDHTTCYP3A4NPC1 | |
| SCHEMBL10213485 | 0.81 | ALDH1A1 (0.56) | ALDH1A1PDK2HSP90AA1HPGDHTT | |
| SCHEMBL3787476 | 0.81 | ALDH1A1 (0.51) | ALDH1A1PDK2HSP90AA1PDK4HPGD | |
| SCHEMBL11576641 | 0.80 | PDK2 (0.68) | ALDH1A1PDK2HSP90AA1PDK4HPGD | |
| SCHEMBL20077098 | 0.79 | ALDH1A1 (0.50) | ALDH1A1PDK2HSP90AA1HPGDHTT | |
| SCHEMBL4500590 | 0.79 | ALDH1A1 (0.74) | ALDH1A1PDK2HPGDHTTCYP3A4 | |
| SCHEMBL30032063 | 0.79 | NPC1 (0.61) | ALDH1A1PDK2HPGDHTTPDK1 | |
| SCHEMBL18931210 | 0.79 | ALDH1A1 (0.50) | ALDH1A1PDK2HPGDHTTCYP3A4 | |
| SCHEMBL3174627 | 0.79 | ALDH1A1 (0.50) | ALDH1A1PDK2HSD17B10HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526196-B1 | ARYL AND HETEROARYL ETHER DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS | MERCK SHARP & DOHME LLC (US) | 2026-03-18 | — | — | EP | disclosed |
| US-11655216-B2 | Aryl and heteroaryl ether derivatives as liver X receptor beta agonists, compositions, and their use | MERCK SHARP & DOHME LLC (US) | 2023-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11655216-B2 | Aryl and heteroaryl ether derivatives as liver X receptor beta agonists, compositions, and their use | NR1H2, NR1H3, NR1H4 | ALDH1A1 894/4885PDK2 2381/4885HSP90AA1 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.