Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28433635 | 1.00 | RET (0.56) | RETCCNE1CDK2TSHRIGF1R | |
| SCHEMBL10060060 | 0.94 | RET (0.56) | RETCCNE1CDK2IGF1RAURKA | |
| SCHEMBL31276189 | 0.85 | RET (0.60) | RETCCNE1CDK2TSHR | |
| SCHEMBL21744548 | 0.82 | RET (0.54) | RETIGF1R | |
| SCHEMBL28429868 | 0.82 | RET (0.56) | RET | |
| SCHEMBL30452755 | 0.82 | RET (0.56) | RET | |
| SCHEMBL10060059 | 0.81 | SYK (0.47) | RETCCNE1CDK2 | |
| SCHEMBL10060058 | 0.81 | RET (0.56) | RETCCNE1CDK2TSHRIGF1R | |
| SCHEMBL3812064 | 0.81 | RET (0.60) | RETCCNE1CDK2TSHRIGF1R | |
| SCHEMBL30250114 | 0.81 | PAK1 (0.51) | RETIGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484479-B | Azacyclic compounds, pharmaceutical compositions containing the same, and methods of making and using the same | 四川科伦博泰生物医药股份有限公司 | 2023-06-13 | — | — | CN | disclosed |