Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 12/20 | 0.54 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21744957 | 0.88 | IGF1R (0.67) | RETIGF1R | |
| SCHEMBL21744951 | 0.85 | RET (0.60) | RETJAK2 | |
| SCHEMBL21744945 | 0.84 | RET (0.52) | RETIGF1R | |
| SCHEMBL20042178 | 0.83 | ACHE (0.56) | RETACHEJAK2 | |
| SCHEMBL31275911 | 0.82 | RET (0.51) | RETIGF1RJAK2 | |
| SCHEMBL22546759 | 0.82 | RET (0.51) | RETIGF1RJAK2 | |
| SCHEMBL30452041 | 0.82 | RET (0.56) | RETIGF1R | |
| SCHEMBL28433635 | 0.82 | RET (0.56) | RETIGF1R | |
| SCHEMBL22534392 | 0.82 | RET (0.53) | RETJAK2 | |
| SCHEMBL30452755 | 0.82 | RET (0.56) | RETJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135896-B | Methylpyrazole derivatives as RET inhibitors | 正大天晴药业集团股份有限公司 | 2024-12-06 | — | — | CN | disclosed |
| CN-111499613-B | N-carboxamide derivatives, method for the production thereof and their use in medicine | 浙江海正药业股份有限公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-111808077-B | Piperazine amide derivatives, process for their preparation and their use in medicine | 浙江海正药业股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| US-20220177450-A1 | PIPERAZINE AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2022-06-09 | — | — | US | disclosed |
| EP-3954680-A1 | PIPERAZINE AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | Zhejiang Hisun Pharmaceutical Co., Ltd. (CN) | 2022-02-16 | — | — | EP | disclosed |
| CN-113135896-A | Methylpyrazole derivatives as RET inhibitors | 正大天晴药业集团股份有限公司 | 2021-07-20 | — | — | CN | disclosed |
| CN-111808077-A | Piperazine amide derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2020-10-23 | — | — | CN | disclosed |
| WO-2020207419-A1 | PIPERAZINE AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | 浙江海正药业股份有限公司 | 2020-10-15 | — | — | WO | disclosed |
| WO-2020207419-A1 | PIPERAZINE AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | 浙江海正药业股份有限公司 | 2020-10-15 | — | — | WO | disclosed |
| CN-111499613-A | N-formamide derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2020-08-07 | — | — | CN | disclosed |
| WO-2020156319-A1 | N-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 浙江海正药业股份有限公司 | 2020-08-06 | — | — | WO | disclosed |
| WO-2020035065-A1 | PYRAZOLE DERIVATIVE AS RET INHIBITOR | 南京明德新药研发有限公司 | 2020-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220177450-A1 | PIPERAZINE AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | WEE1, WEE2, RET | RET 3/4885IGF1R 1563/4885ACHE 3974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.