Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.59 |
| ▸ | ERN1 | O75460 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.55 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | FES | P07332 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29032775 | 1.00 | CFD (0.59) | CFDERN1JAK2MAP4K4CHEK2 | |
| SCHEMBL29032785 | 0.94 | CFD (0.53) | CFDERN1JAK2MAP4K4CHEK2 | |
| SCHEMBL29032791 | 0.91 | USP30 (0.58) | MAP4K4PRKCGROCK1PKN2MAP4K5 | |
| SCHEMBL30452219 | 0.91 | USP30 (0.58) | MAP4K4PRKCGROCK1PKN2MAP4K5 | |
| SCHEMBL30450735 | 0.91 | MMP2 (0.52) | CFDERN1JAK2MAP4K4CHEK2 | |
| SCHEMBL29032725 | 0.91 | MMP2 (0.52) | CFDERN1JAK2MAP4K4CHEK2 | |
| SCHEMBL29032784 | 0.85 | NAMPT (0.56) | ABL1FABP6SMN1; SMN2 | |
| SCHEMBL30451056 | 0.85 | NAMPT (0.56) | ABL1FABP6SMN1; SMN2 | |
| SCHEMBL29032783 | 0.85 | ABL1 (0.56) | CFDERN1JAK2MAP4K4CHEK2 | |
| SCHEMBL30451514 | 0.85 | ABL1 (0.56) | CFDERN1JAK2MAP4K4CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116253686-B | Aminobenzimidazole benzamide derivative and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2023-11-17 | — | — | CN | disclosed |
| CN-116253686-A | Aminobenzimidazole benzamide derivative and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2023-06-13 | — | — | CN | disclosed |