Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.38 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.38 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL488491 | 1.00 | MET (0.48) | METJAK2MAP4K3PIK3CAMTOR | |
| SCHEMBL487528 | 0.86 | MET (0.60) | METJAK2MAP4K3AXLMERTK | |
| SCHEMBL30452905 | 0.86 | MET (0.60) | METJAK2MAP4K3AXLMERTK | |
| SCHEMBL487709 | 0.85 | MET (0.49) | METJAK2MAP4K3ALDH1A1 | |
| SCHEMBL30454688 | 0.85 | MET (0.49) | METJAK2MAP4K3ALDH1A1 | |
| SCHEMBL30452521 | 0.84 | MET (0.53) | METJAK2MAP4K3 | |
| SCHEMBL487713 | 0.84 | MET (0.53) | METJAK2MAP4K3 | |
| SCHEMBL487873 | 0.84 | AXL (0.57) | METJAK2MAP4K3AXLMERTK | |
| SCHEMBL30453612 | 0.84 | AXL (0.57) | METJAK2MAP4K3AXLMERTK | |
| SCHEMBL488069 | 0.81 | ALDH1A1 (0.52) | METJAK2MAP4K3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4599890-A2 | SUNITINIB FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS | Kyoto University (JP) | 2025-08-13 | — | — | EP | disclosed |
| CN-113181362-B | Medicament for preventing and/or treating amyotrophic lateral sclerosis | 国立大学法人京都大学 | 2023-06-13 | — | — | CN | disclosed |