SCHEMBL30452972

SCHEMBL30452972

Nc1ncc(-c2cccc(C(=O)N3CCC[C@H]3CN3CCCC3)c2)cc1OCc1c(F)ccc(F)c1Cl

nearest known ligand 0.84

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MET P08581 14/20 0.84
CSF1R P07333 2/20 0.54
ALK Q9UM73 3/20 0.45
ATR Q13535 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL487656 1.00 MET (0.84) METCSF1RALKATR
SCHEMBL30453391 0.92 MET (1.00) METCSF1RALK
SCHEMBL30454847 0.92 MET (1.00) METCSF1RALK
SCHEMBL487809 0.92 MET (1.00) METCSF1RALK
SCHEMBL5496614 0.92 MET (1.00) METCSF1RALK
SCHEMBL487984 0.92 MET (1.00) METCSF1RALK
SCHEMBL10316972 0.90 MET (0.86) METCSF1RALKATR
SCHEMBL487625 0.90 MET (0.86) METCSF1RALKATR
SCHEMBL30452836 0.90 MET (0.86) METCSF1RALKATR
SCHEMBL487970 0.88 MET (0.66) METCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113181362-B Medicament for preventing and/or treating amyotrophic lateral sclerosis 国立大学法人京都大学 2023-06-13 CN disclosed