SCHEMBL30453430

SCHEMBL30453430

Cc1ccc(C)c(-c2cnc(N)c(OC(C)c3c(Cl)ccc(F)c3Cl)c2)c1

nearest known ligand 0.70

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MET P08581 11/20 0.70
JAK2 O60674 1/20 0.65
ALK Q9UM73 8/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL488719 1.00 MET (0.70) METJAK2ALK
SCHEMBL488285 0.89 MET (0.77) METJAK2ALK
SCHEMBL30452648 0.89 MET (0.77) METJAK2ALK
SCHEMBL30454647 0.86 MET (0.77) METJAK2ALK
SCHEMBL488371 0.86 MET (0.77) METJAK2ALK
SCHEMBL488558 0.85 MET (0.78) METJAK2ALK
SCHEMBL30452833 0.85 MET (0.78) METJAK2ALK
SCHEMBL487929 0.85 MET (0.78) METJAK2ALK
SCHEMBL30453103 0.85 MET (0.78) METJAK2ALK
SCHEMBL13005642 0.85 MET (0.78) METJAK2ALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113181362-B Medicament for preventing and/or treating amyotrophic lateral sclerosis 国立大学法人京都大学 2023-06-13 CN disclosed