Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.41 |
| ▸ | ROS1 | P08922 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487665 | 1.00 | MET (0.46) | METJAK2MAP4K3ROS1ALK | |
| SCHEMBL30453227 | 0.91 | MET (0.45) | METJAK2MAP4K3ROS1ALK | |
| SCHEMBL487959 | 0.91 | MET (0.45) | METJAK2MAP4K3ROS1ALK | |
| SCHEMBL487812 | 0.91 | MET (0.41) | METJAK2MAP4K3ROS1ALK | |
| SCHEMBL30453720 | 0.91 | MET (0.41) | METJAK2MAP4K3ROS1ALK | |
| SCHEMBL488394 | 0.86 | MET (0.50) | METJAK2MAP4K3CYP2C9CYP2C19 | |
| SCHEMBL488144 | 0.84 | ALK (0.55) | METJAK2ROS1ALK | |
| SCHEMBL30453683 | 0.84 | ALK (0.55) | METJAK2ROS1ALK | |
| SCHEMBL488262 | 0.84 | MET (0.49) | METJAK2MAP4K3RIPK2BRAF | |
| SCHEMBL30452927 | 0.84 | MET (0.49) | METJAK2MAP4K3RIPK2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4599890-A2 | SUNITINIB FOR PREVENTING AND/OR TREATING AMYOTROPHIC LATERAL SCLEROSIS | Kyoto University (JP) | 2025-08-13 | — | — | EP | disclosed |
| CN-113181362-B | Medicament for preventing and/or treating amyotrophic lateral sclerosis | 国立大学法人京都大学 | 2023-06-13 | — | — | CN | disclosed |