Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211335 | 0.88 | LOXL2 (0.63) | LOXL2CYP4A11CYP4F2TSHRRAB9A | |
| SCHEMBL7174070 | 0.83 | TSHR (0.58) | LOXL2CYP4A11CYP4F2TSHRRAB9A | |
| SCHEMBL22664443 | 0.78 | LOXL2 (0.51) | LOXL2CYP4A11CYP4F2TSHRRAB9A | |
| SCHEMBL11459316 | 0.75 | PTGS1 (0.64) | LOXL2CYP4A11TSHRPOLBMAPT | |
| SCHEMBL20259350 | 0.74 | LOXL2 (0.66) | LOXL2CYP4A11CYP4F2TSHRRAB9A | |
| SCHEMBL131711 | 0.74 | LOXL2 (0.70) | LOXL2CYP4A11CYP4F2TSHRRAB9A | |
| SCHEMBL70185 | 0.74 | CYP4A11 (0.75) | LOXL2CYP4A11CYP4F2TSHRNPC1 | |
| SCHEMBL69454 | 0.74 | LOXL2 (0.70) | LOXL2CYP4A11CYP4F2TSHRNPC1 | |
| SCHEMBL1811746 | 0.74 | LOXL2 (0.59) | LOXL2CYP4A11CYP4F2TSHRRAB9A | |
| SCHEMBL661620 | 0.74 | CYP4A11 (0.64) | LOXL2CYP4A11CYP4F2TSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116438179-A | Pyrazole derivatives as RET kinase inhibitors | 伊莱利利公司 | 2023-07-14 | — | — | CN | disclosed |