Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 4/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25673290 | 1.00 | MAPT (0.49) | MAPTNPC1RAB9ACASP3SENP8 | |
| SCHEMBL25225421 | 0.85 | MAPT (0.49) | MAPTNPC1RAB9ACASP3SENP8 | |
| SCHEMBL25269391 | 0.85 | MAPT (0.49) | MAPTNPC1RAB9ACASP3SENP8 | |
| SCHEMBL25673309 | 0.81 | DPP4 (0.46) | MAPTNPC1RAB9ATP53MAPK1 | |
| SCHEMBL25674622 | 0.76 | KDM1A (0.45) | MAPTNPC1RAB9ATP53KDM1A | |
| SCHEMBL30456874 | 0.75 | MAPT (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25673289 | 0.75 | MAPT (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25598272 | 0.66 | NPC1 (0.53) | MAPTNPC1RAB9ACASP3SENP8 | |
| SCHEMBL8866913 | 0.66 | HDAC1 (0.56) | MAPTNPC1RAB9ATP53KDM1A | |
| SCHEMBL8867613 | 0.66 | MGLL (0.56) | MAPTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12084453-B2 | Bicyclic amines as CDK12 inhibitors | INCYTE CORPORATION (US) | 2024-09-10 | — | — | US | disclosed |
| WO-2023107705-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-15 | — | — | WO | disclosed |
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | CDK12, CDK1, CDK2 | MAPT 1617/4885NPC1 4063/4885RAB9A 4139/4885 |
| US-12084453-B2 | Bicyclic amines as CDK12 inhibitors | CDK12, CDK1, CDK2 | MAPT 1617/4885NPC1 4063/4885RAB9A 4139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.