Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | SCD | O00767 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30456874 | 1.00 | MAPT (0.53) | MAPTALDH1A1NPC1TP53TSHR | |
| SCHEMBL25278053 | 0.78 | TRPV1 (0.52) | MAPTNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL3795024 | 0.77 | POLB (0.68) | MAPTALDH1A1NPC1TP53TSHR | |
| SCHEMBL8866913 | 0.76 | HDAC1 (0.56) | MAPTALDH1A1NPC1TP53TSHR | |
| SCHEMBL7383453 | 0.76 | MAPT (0.72) | MAPTALDH1A1NPC1TP53TSHR | |
| SCHEMBL8867613 | 0.76 | MGLL (0.56) | MAPTALDH1A1NPC1TP53TSHR | |
| SCHEMBL30456954 | 0.75 | MAPT (0.49) | MAPTALDH1A1NPC1TP53TSHR | |
| SCHEMBL25673290 | 0.75 | MAPT (0.49) | MAPTALDH1A1NPC1TP53TSHR | |
| SCHEMBL1887693 | 0.74 | HDAC1 (0.69) | MAPTALDH1A1NPC1TP53TSHR | |
| SCHEMBL3586214 | 0.74 | MGLL (0.52) | MAPTALDH1A1NPC1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | CDK12, CDK1, CDK2 | MAPT 1617/4885ALDH1A1 4394/4885NPC1 4063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.