Known targets — ChEMBL curated mechanism
PIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5
The experimentally established mechanism targets of Pictilisib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA known ✓ | P42336 | 16/20 | 0.90 |
| ▸ | PIK3CD known ✓ | O00329 | 15/20 | 0.90 |
| ▸ | PIK3CB known ✓ | P42338 | 14/20 | 0.90 |
| ▸ | PIK3CG known ✓ | P48736 | 12/20 | 0.90 |
| ▸ | PIK3R2 known ✓ | O00459 | 1/20 | 0.90 |
| ▸ | PIK3R1 known ✓ | P27986 | 1/20 | 0.90 |
| ▸ | PIK3R5 known ✓ | Q8WYR1 | 1/20 | 0.90 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.92 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.92 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.90 |
| ▸ | PLK4 | O00444 | 1/20 | 0.90 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.90 |
| ▸ | GAK | O14976 | 1/20 | 0.90 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.90 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.90 |
| ▸ | STK16 | O75716 | 1/20 | 0.90 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.90 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.90 |
| ▸ | NQO2 | P16083 | 1/20 | 0.90 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pictilisib SCHEMBL29370279 | 0.96 | ABCC4 (1.00) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| Pictilisib SCHEMBL29915227 | 0.96 | ABCC4 (1.00) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| Pictilisib SCHEMBL29387739 | 0.95 | PIK3CA (1.00) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| Pictilisib SCHEMBL29375636 | 0.95 | PIK3CA (1.00) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| Pictilisib SCHEMBL14859338 | 0.95 | PIK3CA (1.00) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| Pictilisib SCHEMBL190812 | 0.95 | PIK3CA (1.00) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| SCHEMBL190513 | 0.93 | PIK3CA (0.95) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| Pictilisib SCHEMBL31237882 | 0.91 | PIK3CA (0.89) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| SCHEMBL31205 | 0.89 | PIK3CA (0.88) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB | |
| SCHEMBL190211 | 0.88 | PIK3CA (0.87) | ABCC4ABCB11PIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024372-B1 | THIENO[3,2-D]PYRIMIDINE DERIVATIVE USEFUL AS PI3K INHIBITOR | HOFFMANN LA ROCHE (CH) | 2010-06-23 | — | — | EP | claimed |