Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25236981 | 1.00 | MAPT (0.50) | MAPTKDM4EKMT2AHPGDALDH1A1 | |
| SCHEMBL30457729 | 0.88 | CA12 (0.49) | MAPTKDM4EHPGDALDH1A1LMNA | |
| SCHEMBL7399022 | 0.88 | MAPT (0.50) | MAPTKDM4EKMT2AHPGDALDH1A1 | |
| SCHEMBL25278897 | 0.88 | CA12 (0.49) | MAPTKDM4EHPGDALDH1A1LMNA | |
| SCHEMBL29678875 | 0.87 | MAPT (0.64) | MAPTKDM4EKMT2AHPGDALDH1A1 | |
| SCHEMBL5169870 | 0.87 | MAPT (0.64) | MAPTKDM4EKMT2AHPGDALDH1A1 | |
| SCHEMBL7927917 | 0.85 | ALDH1A1 (0.50) | MAPTKDM4EKMT2AHPGDALDH1A1 | |
| SCHEMBL11238694 | 0.83 | TSHR (0.61) | MAPTKDM4EKMT2AALDH1A1RAB9A | |
| SCHEMBL3990255 | 0.83 | KDM4E (0.47) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL6931187 | 0.82 | CYP1A2 (0.63) | MAPTKDM4EKMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448508-A1 | BENZOTHIOPHENE DERIVATIVES AS RXFP1 AGONISTS | Bristol-Myers Squibb Company (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114823-A1 | BENZOTHIOPHENE DERIVATIVES AS RXFP1 AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-22 | — | — | WO | disclosed |