Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25234076 | 1.00 | NPC1 (0.35) | NPC1SCN4ARAB9ASMN1; SMN2LPL | |
| SCHEMBL13721705 | 0.79 | MAPK1 (0.34) | LPLLIPGSNCAUSP30 | |
| SCHEMBL16010464 | 0.79 | LPL (0.42) | NPC1RAB9ALPLLIPGSNCA | |
| SCHEMBL17669989 | 0.79 | PDGFRB (0.35) | NPC1RAB9ASMN1; SMN2LPLLIPG | |
| SCHEMBL119228 | 0.76 | LPL (0.44) | LPLLIPGHDAC3HDAC1HDAC2 | |
| SCHEMBL4339028 | 0.75 | CYP2A6 (0.41) | LPLLIPGSNCAPDGFRBKDR | |
| SCHEMBL20984011 | 0.75 | LIPG (0.51) | LPLLIPGSNCAPDGFRBKDR | |
| SCHEMBL4291980 | 0.75 | PDGFRB (0.39) | SCN4ALPLLIPGHDAC6SNCA | |
| SCHEMBL12162014 | 0.74 | LPL (0.35) | LPLLIPGSNCA | |
| SCHEMBL15581069 | 0.74 | LPL (0.45) | LPLLIPGSNCAPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4447963-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023111990-A1 | SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |