Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.42 |
| ▸ | GCK | P35557 | 11/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25281477 | 1.00 | NPC1 (0.46) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL8858696 | 0.83 | GRAMD1A (0.55) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL3666966 | 0.81 | NPC1 (0.54) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL20792856 | 0.80 | DPP4 (0.53) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL18703636 | 0.79 | NPC1 (0.54) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL8858771 | 0.76 | NPC1 (0.47) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL8858610 | 0.76 | NPC1 (0.53) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL8858676 | 0.76 | GRAMD1A (0.51) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL8858814 | 0.75 | NPC1 (0.47) | NPC1RAB9AFGFR3KDRGRAMD1A | |
| SCHEMBL3574338 | 0.75 | GRAMD1A (0.50) | NPC1RAB9AFGFR3KDRGRAMD1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448500-A1 | BENZOTHIAZOLE, BENZOISOXAZOLE AND BENZODIOXOLE ANALOGS AS RXFP1 RECEPTOR AGONISTS | Bristol-Myers Squibb Company (US) | 2024-10-23 | — | — | EP | disclosed |
| CN-118401502-A | Benzothiazole, benzisoxazole and benzodioxole analogs as RXFP1 receptor agonists | 百时美施贵宝公司 | 2024-07-26 | — | — | CN | disclosed |
| WO-2023114822-A1 | BENZOTHIAZOLE, BENZOISOXAZOLE AND BENZODIOXOLE ANALOGS AS RXFP1 RECEPTOR AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-22 | — | — | WO | disclosed |