SCHEMBL30458312

SCHEMBL30458312

[2H]c1cc2c(cc1F)C(=O)N(C1CCC(=O)NC1=O)C2

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 20/20 0.65
DDB1 Q16531 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20233779 0.89 CRBN (0.73) CRBNDDB1
SCHEMBL29884126 0.89 CRBN (0.73) CRBNDDB1
SCHEMBL30496981 0.89 CRBN (0.73) CRBNDDB1
SCHEMBL30459200 0.86 CRBN (0.69) CRBNDDB1
SCHEMBL30716599 0.81 CRBN (0.73) CRBNDDB1
SCHEMBL21622030 0.81 CRBN (0.73) CRBNDDB1
SCHEMBL29876913 0.81 CRBN (0.69) CRBNDDB1
SCHEMBL22557008 0.81 CRBN (0.69) CRBNDDB1
SCHEMBL24186805 0.80 CRBN (0.75) CRBN
SCHEMBL22703755 0.79 CRBN (0.73) CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023104155-A1 LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF 标新生物医药科技(上海)有限公司 2023-06-15 WO claimed
WO-2023104155-A1 LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF 标新生物医药科技(上海)有限公司 2023-06-15 WO disclosed