Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | SPR | P35270 | 4/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.35 |
| ▸ | EIF4E | P06730 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033937 | 1.00 | RIPK1 (0.42) | RIPK1NAMPTSPRPDE5APDE4A | |
| SCHEMBL1752110 | 1.00 | RIPK1 (0.42) | RIPK1NAMPTSPRPDE5APDE4A | |
| SCHEMBL1750125 | 0.94 | RIPK1 (0.41) | RIPK1NAMPTSPRPDE5APDE4A | |
| SCHEMBL1750671 | 0.93 | RIPK1 (0.41) | RIPK1NAMPTSPRPDE5APDE4A | |
| SCHEMBL1750369 | 0.88 | RIPK1 (0.46) | RIPK1PDE5APDE4APDE1APDE1B | |
| SCHEMBL1750051 | 0.88 | RIPK1 (0.46) | RIPK1PDE5APDE4APDE1APDE1B | |
| SCHEMBL1750368 | 0.88 | RIPK1 (0.46) | RIPK1PDE5APDE4APDE1APDE1B | |
| SCHEMBL1751913 | 0.83 | RIPK1 (0.39) | RIPK1NAMPTMGLLHTR2B | |
| SCHEMBL12529152 | 0.83 | HDAC6 (0.36) | RIPK1NAMPTSPRPDE5APDE4A | |
| SCHEMBL2301303 | 0.81 | NAMPT (0.41) | NAMPTSPREIF4EMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035379-B1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2010-06-16 | — | — | EP | claimed |