Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2227219 | 0.84 | MAOB (0.46) | HSD17B10RAB9AMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL2227227 | 0.82 | MAOB (0.45) | HSD17B10RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL67612 | 0.81 | MAOB (0.50) | RAB9ANPC1SMN1; SMN2ARALDH1A1 | |
| SCHEMBL5539912 | 0.78 | HSD17B10 (0.45) | HSD17B10RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL3152242 | 0.76 | MEN1 (0.59) | HSD17B10RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL3223921 | 0.76 | MAPT (0.60) | HSD17B10RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL1143565 | 0.76 | APP (0.55) | HSD17B10RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL1429528 | 0.76 | MAPT (0.47) | HSD17B10RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL95448 | 0.76 | MMP12 (0.51) | HSD17B10RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL13464653 | 0.76 | HSD17B10 (0.44) | HSD17B10RAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4566612-A2 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | Recurium IP Holdings, LLC (US) | 2025-06-11 | — | — | EP | disclosed |
| EP-3762385-B1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | RECURIUM IP HOLDINGS LLC (US) | 2025-02-12 | — | — | EP | disclosed |
| US-20240391924-A1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | RECURIUM IP HOLDINGS, LLC | 2024-11-28 | — | — | US | disclosed |
| CN-117720541-A | Substituted 1, 2-dihydro-3H-pyrazolo [3,4-d ] pyrimidin-3-ones | 里科瑞尔姆IP控股有限责任公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-117285532-A | Substituted 1, 2-dihydro-3H-pyrazolo [3,4-d ] pyrimidin-3-ones | 里科瑞尔姆IP控股有限责任公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-111902413-B | Substituted 1, 2-dihydro-3H-pyrazolo [3,4-d ] pyrimidin-3-ones | 里科瑞尔姆IP控股有限责任公司 | 2023-10-17 | — | — | CN | disclosed |
| WO-2023134656-A1 | PEPTIDYL NITRILE COMPOUND AND USE THEREOF | 上海壹典医药科技开发有限公司 | 2023-07-20 | — | — | WO | disclosed |
| US-11261192-B2 | Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones | RECURIUM IP HOLDINGS, LLC (US) | 2022-03-01 | — | — | US | disclosed |
| US-20220024939-A1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | RECURIUM IP HOLDINGS, LLC | 2022-01-27 | — | — | US | disclosed |
| US-20210139482-A1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | RECURIUM IP HOLDINGS, LLC | 2021-05-13 | — | — | US | disclosed |
| US-20100003191-A1 | AURONE DERIVATIVE-CONTAINING COMPOSITION FOR DIAGNOSIS | NAGASAKI UNIVERSITY (JP) | 2010-01-07 | — | — | US | disclosed |
| US-20100003191-A1 | AURONE DERIVATIVE-CONTAINING COMPOSITION FOR DIAGNOSIS | NAGASAKI UNIVERSITY (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2113258-A1 | AURONE DERIVATIVE-CONTAINING COMPOSITION FOR DIAGNOSIS | Nagasaki University (JP) | 2009-11-04 | — | — | EP | disclosed |
| EP-2113258-A1 | AURONE DERIVATIVE-CONTAINING COMPOSITION FOR DIAGNOSIS | Nagasaki University (JP) | 2009-11-04 | — | — | EP | disclosed |
| US-6391902-B2 | TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION SUCH AS INCONTINENCE AND IRRITABLE BOWEL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | disclosed |
| CN-1333774-A | Substituted benzofuranodindoles and indenoindoles as novel potassium channel openers | AMERICAN HOME PROD (US) | 2002-01-30 | — | — | CN | disclosed |
| US-20010047026-A1 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-29 | — | — | US | disclosed |
| EP-1135393-A2 | SUBSTITUTED BENZOFURANOINDOLES AND INDENOINDOLES AS NOVEL POTASSIUM CHANNEL OPENERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6288099-B1 | COMPOUNDS SUCH AS 8-BROMO-10H-BENZO(4,5)FURO(3,2-B)INDOLE-1-CARBOXYLIC ACID USED TO TREAT DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRATION SUCH AS URINARY INCONTINENCE AND IRRITABLE BOWL SYNDROME | AMERICAN HOME PRODUCTS CORPORATION | 2001-09-11 | — | — | US | disclosed |
| WO-2000034285-A2 | SUBSTITUTED BENZOFURANOINDOLES AND INDENOINDOLES AS NOVEL POTASSIUM CHANNEL OPENERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11261192-B2 | Substituted 1,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-ones | MKI67, BRCA1, CCNI | HSD17B10 1017/4885RAB9A 870/4885MEN1 2466/4885 |
| US-20010047026-A1 | Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers | KCNJ2, KCNN3, KCNN2 | HSD17B10 2898/4885RAB9A 2569/4885MEN1 2213/4885 |
| US-20210139482-A1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | MKI67, BRCA1, CCNI | HSD17B10 1017/4885RAB9A 870/4885MEN1 2466/4885 |
| US-20220024939-A1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | MKI67, BRCA1, CCNI | HSD17B10 1017/4885RAB9A 870/4885MEN1 2466/4885 |
| US-20100003191-A1 | AURONE DERIVATIVE-CONTAINING COMPOSITION FOR DIAGNOSIS | APP, APBA1, BACE1 | HSD17B10 881/4885RAB9A 565/4885MEN1 508/4885 |
| US-20240391924-A1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | MKI67, BRCA1, CCNI | HSD17B10 1017/4885RAB9A 870/4885MEN1 2466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.