Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29041935 | 1.00 | CHRNB2 (0.37) | CHRNB2CHRNA4CYP11B1CYP11B2 | |
| SCHEMBL25875530 | 0.85 | CHRNB2 (0.35) | CHRNB2CHRNA4CYP11B1CYP11B2 | |
| SCHEMBL31370480 | 0.84 | CHRNB2 (0.39) | CHRNB2CHRNA4 | |
| SCHEMBL19552036 | 0.84 | — | — | |
| SCHEMBL29041927 | 0.81 | CYP11B1 (0.36) | CHRNB2CHRNA4CYP11B1CYP11B2 | |
| SCHEMBL29041953 | 0.79 | TRPV1 (0.40) | CHRNB2CHRNA4CYP11B1CYP11B2 | |
| SCHEMBL23540497 | 0.77 | CHRNB2 (0.43) | CHRNB2CHRNA4 | |
| SCHEMBL23124495 | 0.75 | PPARA (0.45) | — | |
| SCHEMBL26564825 | 0.74 | CYP3A4 (0.32) | — | |
| SCHEMBL17969392 | 0.73 | CA12 (0.38) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116457346-A | Preparation of indolone derivatives as novel diacylglycerol O-acyltransferase 2 inhibitors | 默沙东有限责任公司 | 2023-07-18 | — | — | CN | disclosed |