Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 18/20 | 0.59 |
| ▸ | THRA | P10827 | 4/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30460696 | 1.00 | THRB (0.59) | THRBTHRAPDE10AMCHR1 | |
| SCHEMBL30460748 | 0.92 | THRB (0.53) | THRBTHRA | |
| SCHEMBL30460714 | 0.84 | THRB (0.58) | THRBTHRA | |
| SCHEMBL6216771 | 0.81 | THRB (0.70) | THRBTHRA | |
| SCHEMBL31301036 | 0.81 | THRB (0.40) | THRBTHRAPDE10A | |
| SCHEMBL25769192 | 0.75 | THRB (0.47) | THRBTHRAPDE10A | |
| SCHEMBL30460708 | 0.75 | THRB (0.53) | THRBTHRA | |
| SCHEMBL6216239 | 0.74 | THRB (0.74) | THRBTHRA | |
| SCHEMBL6217449 | 0.74 | THRB (0.74) | THRBTHRA | |
| SCHEMBL6216674 | 0.74 | THRB (0.66) | THRBTHRAMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4458820-A1 | CLASS OF QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2024-11-06 | — | — | EP | claimed |
| EP-4458820-A1 | CLASS OF QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2024-11-06 | — | — | EP | disclosed |
| CN-118871435-A | Quinoline compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2024-10-29 | — | — | CN | disclosed |
| WO-2023125716-A1 | CLASS OF QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 中国科学院上海药物研究所 | 2023-07-06 | — | — | WO | disclosed |
| CN-116354934-A | Quinoline compound, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2023-06-30 | — | — | CN | disclosed |