Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | LGMN | Q99538 | 2/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548994 | 1.00 | GAA (0.67) | GAAMAPTUSP2ATMLGMN | |
| SCHEMBL31516231 | 0.94 | GAA (0.62) | GAAMAPTUSP2ATMLGMN | |
| SCHEMBL30637174 | 0.86 | ALDH1A1 (0.61) | GAAMAPTALDH1A1CYP2C19KMT2A | |
| SCHEMBL31401064 | 0.86 | ALDH1A1 (0.61) | GAAMAPTALDH1A1CYP2C19KMT2A | |
| SCHEMBL31401389 | 0.86 | ALDH1A1 (0.61) | GAAMAPTALDH1A1CYP2C19KMT2A | |
| SCHEMBL31401347 | 0.85 | KDM4E (0.61) | GAAMAPTGPR119ALDH1A1KMT2A | |
| SCHEMBL30664035 | 0.85 | KDM4E (0.61) | GAAMAPTGPR119ALDH1A1KMT2A | |
| SCHEMBL21180884 | 0.84 | MAPT (0.62) | GAAMAPTLGMNALDH1A1CYP2C19 | |
| SCHEMBL1648624 | 0.84 | MAPT (0.64) | GAAMAPTLGMNALDH1A1CYP2C19 | |
| SCHEMBL5913512 | 0.84 | MAPT (0.67) | MAPTLGMNALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118660872-A | Pyrimidine compound, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-116496252-A | Pyrimidine compound, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2023-07-28 | — | — | CN | disclosed |