Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30637174 | 1.00 | ALDH1A1 (0.61) | ALDH1A1GAASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL31401389 | 1.00 | ALDH1A1 (0.61) | ALDH1A1GAASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL31516231 | 0.93 | GAA (0.62) | ALDH1A1GAASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL4684573 | 0.86 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2CYP2C19MAPTKMT2A | |
| SCHEMBL30462011 | 0.86 | GAA (0.67) | ALDH1A1GAACYP2C19MAPTKMT2A | |
| SCHEMBL2548994 | 0.86 | GAA (0.67) | ALDH1A1GAACYP2C19MAPTKMT2A | |
| SCHEMBL31175186 | 0.86 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2CYP2C19KMT2AHPGD | |
| SCHEMBL30637198 | 0.83 | ALDH1A1 (0.56) | ALDH1A1GAASMN1; SMN2CYP2C19CYP1A2 | |
| SCHEMBL24873099 | 0.82 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL30637176 | 0.81 | HSD17B10 (0.53) | ALDH1A1GAASMN1; SMN2CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |