Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BRD1 | O95696 | 1/20 | 0.31 |
| ▸ | TAF1 | P21675 | 1/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25225783 | 1.00 | HSD11B1 (0.36) | HSD11B1ALDH1A1LMNAAGTR1RAB9A | |
| SCHEMBL25223448 | 0.80 | HSD11B1 (0.35) | HSD11B1ALDH1A1TRPV1 | |
| SCHEMBL30533962 | 0.80 | HSD11B1 (0.35) | HSD11B1ALDH1A1TRPV1 | |
| SCHEMBL25281606 | 0.80 | HSD11B1 (0.35) | HSD11B1ALDH1A1TRPV1 | |
| SCHEMBL30533961 | 0.80 | HSD11B1 (0.35) | HSD11B1ALDH1A1TRPV1 | |
| SCHEMBL25599429 | 0.75 | HSD11B1 (0.38) | HSD11B1ALDH1A1LMNARAB9AMAPT | |
| SCHEMBL25222611 | 0.68 | KCNH2 (0.36) | HSD11B1ALDH1A1SMN1; SMN2MAPTTRPV1 | |
| SCHEMBL30533956 | 0.68 | GAA (0.34) | HSD11B1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL25221933 | 0.68 | GAA (0.34) | HSD11B1ALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL30464382 | 0.68 | KCNH2 (0.36) | HSD11B1ALDH1A1SMN1; SMN2MAPTTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203010-A1 | BICYCLIC AMINE CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-29 | — | — | US | disclosed |
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203010-A1 | BICYCLIC AMINE CDK12 INHIBITORS | CDK12, CDK1, CDK2 | HSD11B1 2253/4885ALDH1A1 4330/4885LMNA 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.