Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599242 | 0.85 | ALDH1A1 (0.40) | HSD11B1HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL25599182 | 0.85 | LMNA (0.45) | HSD11B1HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL30533962 | 0.82 | HSD11B1 (0.35) | HSD11B1ALDH1A1KCNH2TRPV1 | |
| SCHEMBL30533961 | 0.82 | HSD11B1 (0.35) | HSD11B1ALDH1A1KCNH2TRPV1 | |
| SCHEMBL25281606 | 0.82 | HSD11B1 (0.35) | HSD11B1ALDH1A1KCNH2TRPV1 | |
| SCHEMBL25223448 | 0.82 | HSD11B1 (0.35) | HSD11B1ALDH1A1KCNH2TRPV1 | |
| SCHEMBL30464352 | 0.75 | HSD11B1 (0.36) | HSD11B1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL25225783 | 0.75 | HSD11B1 (0.36) | HSD11B1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL25599264 | 0.75 | KCNH2 (0.44) | HSD11B1ALDH1A1MEN1KMT2AKCNH2 | |
| SCHEMBL25681380 | 0.74 | CTSC (0.40) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |