Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 3/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723106 | 0.93 | HTR2C (0.63) | LMNAKMT2AHPGDHTR2CHTR1A | |
| SCHEMBL3282269 | 0.91 | LMNA (0.68) | LMNAKMT2AHPGDSMN1; SMN2HTT | |
| SCHEMBL302243 | 0.91 | LMNA (0.62) | LMNAKMT2AHPGDSMN1; SMN2HTT | |
| SCHEMBL13065013 | 0.87 | CNR2 (0.61) | LMNAKMT2AHPGDSMN1; SMN2HTT | |
| SCHEMBL1711156 | 0.87 | LMNA (0.62) | LMNAKMT2AHPGDHTR2CHTR1A | |
| SCHEMBL303307 | 0.87 | LMNA (0.71) | LMNAKMT2AHPGDSMN1; SMN2HTT | |
| SCHEMBL2813139 | 0.85 | LMNA (0.62) | LMNAKMT2AHPGDSMN1; SMN2HTT | |
| SCHEMBL1711351 | 0.85 | LMNA (0.62) | LMNAKMT2AHPGDSMN1; SMN2HTT | |
| SCHEMBL302427 | 0.83 | KMT2A (0.68) | LMNAKMT2AHPGDSMN1; SMN2HTT | |
| SCHEMBL13065037 | 0.83 | LMNA (0.63) | LMNAKMT2AHPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500834-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | claimed |
| WO-2010023445-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |