SCHEMBL30465758

SCHEMBL30465758

CNCCOc1ccc2ccccc2n1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
HTR1B P28222 4/20 0.53
HTR1D P28221 2/20 0.53
SLC6A4 P31645 2/20 0.47
HRH1 P35367 2/20 0.47
NCF1 P14598 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
ALDH1A1 P00352 2/20 0.42
HPGD P15428 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
ATM Q13315 1/20 0.42
CHRNB2 P17787 1/20 0.41
CHRNA4 P43681 1/20 0.41
CYP1A2 P05177 1/20 0.40
KDM4E B2RXH2 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4269051 0.81 MEN1 (0.61) MAPTMEN1KMT2ANCF1ALDH1A1
SCHEMBL30060467 0.81 MEN1 (0.61) MAPTMEN1KMT2ANCF1ALDH1A1
SCHEMBL28973292 0.81 MAPT (0.54) MAPTMEN1KMT2ANCF1SMN1; SMN2
SCHEMBL27696506 0.79 MAPT (0.59) MAPTMEN1KMT2ANCF1SMN1; SMN2
SCHEMBL4273391 0.79 MAPT (0.59) MAPTMEN1KMT2AHTR1BHTR1D
SCHEMBL368050 0.78 TLR8 (0.59) MAPTMEN1KMT2AHTR1BSMN1; SMN2
SCHEMBL9199234 0.77 MEN1 (0.61) MAPTMEN1KMT2ANCF1CYP1A2
SCHEMBL9663555 0.77 MAPT (0.61) MAPTMEN1KMT2ANCF1SMN1; SMN2
SCHEMBL5735971 0.77 MEN1 (0.61) MAPTMEN1KMT2ANCF1CYP1A2
SCHEMBL9191448 0.77 MAPT (0.61) MAPTMEN1KMT2ASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4448510-A1 INHIBITORS OF MET KINASE Kinnate Biopharma Inc. (US) 2024-10-23 EP disclosed
WO-2023114809-A1 INHIBITORS OF MET KINASE KINNATE BIOPHARMA INC. (US) 2023-06-22 WO disclosed