Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 12/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30468018 | 1.00 | DGAT2 (0.37) | DGAT2GPR6PRKAA2PRKAB2PRKAG1 | |
| SCHEMBL26388448 | 0.92 | DGAT2 (0.39) | DGAT2GPR6PRKAA2 | |
| SCHEMBL30467995 | 0.92 | DGAT2 (0.39) | DGAT2GPR6PRKAA2 | |
| SCHEMBL30467952 | 0.89 | DGAT2 (0.38) | DGAT2GPR6PRKAA2USP30AR | |
| SCHEMBL30468000 | 0.89 | DGAT2 (0.38) | DGAT2GPR6PRKAA2USP30AR | |
| SCHEMBL30468015 | 0.86 | IRAK4 (0.36) | DGAT2GPR6 | |
| SCHEMBL25837892 | 0.84 | USP30 (0.34) | DGAT2GPR6PRKAA2USP30AR | |
| SCHEMBL30467966 | 0.83 | HDAC1 (0.38) | USP30 | |
| SCHEMBL30468009 | 0.83 | HDAC1 (0.38) | USP30 | |
| SCHEMBL30468069 | 0.83 | TBK1 (0.36) | DGAT2GPR6PRKAA2PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161920-A1 | N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2023-04-12 | — | — | EP | claimed |
| EP-4161920-A1 | N-CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | Mission Therapeutics Limited (GB) | 2023-04-12 | — | — | EP | disclosed |