SCHEMBL30468375

SCHEMBL30468375

CCOC(=O)c1cc(-c2ccc3nc(NC(=O)COCc4ccccc4)cn3n2)cnc1C

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 19/20 0.55
PIK3CA P42336 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22371382 1.00 RIPK1 (0.55) RIPK1PIK3CA
SCHEMBL22397192 0.92 RIPK1 (0.48) RIPK1PIK3CA
SCHEMBL22371197 0.92 RIPK1 (0.58) RIPK1
SCHEMBL30468372 0.92 RIPK1 (0.58) RIPK1
Lithium Ion SCHEMBL29849729 0.89 RIPK1 (0.56) RIPK1
SCHEMBL22371359 0.85 RIPK1 (0.58) RIPK1
SCHEMBL30468327 0.84 PIK3CA (0.66) RIPK1PIK3CA
SCHEMBL22370937 0.84 PIK3CA (0.66) RIPK1PIK3CA
SCHEMBL22371320 0.84 RIPK1 (0.59) RIPK1
Lithium Ion SCHEMBL29849584 0.82 RIPK1 (0.57) RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111566103-B Aminoimidazopyrazines as kinase inhibitors 百时美施贵宝公司 2023-06-23 CN disclosed