Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 5/20 | 0.37 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.37 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.37 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25281431 | 1.00 | NPY5R (0.44) | NPY5RCYP19A1TRPV1CNR1CCR1 | |
| SCHEMBL25274819 | 0.83 | NPY5R (0.48) | NPY5RCYP19A1CACNA1HLMNAPOLB | |
| SCHEMBL30469123 | 0.83 | NPY5R (0.48) | NPY5RCYP19A1CACNA1HLMNAPOLB | |
| SCHEMBL30469100 | 0.82 | GRIA2 (0.45) | NPY5RCNR1CCR1TEAD1TEAD4 | |
| SCHEMBL25281888 | 0.82 | GRIA2 (0.45) | NPY5RCNR1CCR1TEAD1TEAD4 | |
| SCHEMBL25230406 | 0.80 | NPY5R (0.41) | NPY5RTRPV1CNR1CCR1TEAD1 | |
| SCHEMBL25278984 | 0.79 | TEAD1 (0.43) | NPY5RCNR1CCR1TEAD1TEAD4 | |
| SCHEMBL30469111 | 0.78 | GRIA2 (0.49) | NPY5RCNR1CCR1TEAD1TEAD4 | |
| SCHEMBL25233252 | 0.78 | GRIA2 (0.49) | NPY5RCNR1CCR1TEAD1TEAD4 | |
| SCHEMBL25275654 | 0.75 | NPY5R (0.39) | NPY5RCNR1CCR1TEAD1TEAD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | CISTIM LEUVEN VZW (BE) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230202985-A1 | Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD | YAP1, TEAD2, TEAD3 | NPY5R 2669/4885CYP19A1 2600/4885TRPV1 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.