Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.58 |
| ▸ | CCR5 | P51681 | 1/20 | 0.58 |
| ▸ | CCR8 | P51685 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16542435 | 1.00 | CCR1 (0.58) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL14569988 | 0.83 | CCR1 (0.52) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL19713104 | 0.83 | CCR1 (0.52) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL16385299 | 0.83 | HSD17B1 (0.55) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL3342956 | 0.83 | CYP11B1 (0.52) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL30751969 | 0.83 | CCR1 (0.52) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL17051514 | 0.83 | CCR1 (0.75) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL12128014 | 0.82 | CCR1 (0.60) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL13483666 | 0.81 | CCR1 (0.71) | CCR1CCR5CCR8HDAC6CYP3A4 | |
| SCHEMBL2477927 | 0.81 | CCR1 (0.71) | CCR1CCR5CCR8HDAC6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4188920-A1 | PIPERIDIN-1-YL-N-PYRYDINE-3-YL-2-OXOACETAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF MTAP-DEFICIENT AND/OR MTA-ACCUMULATING CANCERS | Tango Therapeutics, Inc. (US) | 2023-06-07 | — | — | EP | disclosed |