Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25214900 | 1.00 | MAPT (0.52) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL6575703 | 0.84 | CA1 (0.61) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL25216649 | 0.83 | MAPT (0.66) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL25219864 | 0.81 | MAPT (0.56) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL14012582 | 0.81 | CES2 (0.59) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL29664708 | 0.81 | CES2 (0.59) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL383936 | 0.81 | CES2 (0.59) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL31511812 | 0.79 | TSHR (0.53) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL692907 | 0.78 | ALDH1A1 (0.53) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL4652494 | 0.78 | ERN1 (0.64) | MAPTKMT2AMEN1MAPK1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4441033-A1 | NOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF | Tango Therapeutics, Inc. (US) | 2024-10-09 | — | — | EP | disclosed |
| WO-2023102162-A1 | TGONOVEL HDAC INHIBITORS AND THERAPEUTIC USE THEREOF | TANGO THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | WO | disclosed |