Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035207 | 1.00 | CRBN (0.37) | CRBNDDB1IKZF3POLBPDE3B | |
| SCHEMBL30479046 | 0.90 | CRBN (0.36) | CRBNDDB1IKZF3POLBDRD2 | |
| SCHEMBL25031339 | 0.90 | CRBN (0.36) | CRBNDDB1IKZF3POLBDRD2 | |
| SCHEMBL30965602 | 0.86 | CRBN (0.38) | CRBNDDB1IKZF3POLB | |
| SCHEMBL30981492 | 0.84 | CRBN (0.40) | CRBNDDB1POLB | |
| SCHEMBL25935225 | 0.81 | CRBN (0.43) | CRBNDDB1IKZF3POLBPDE3B | |
| SCHEMBL25935381 | 0.81 | CRBN (0.40) | CRBNDDB1POLB | |
| SCHEMBL25823256 | 0.81 | CRBN (0.48) | CRBNDDB1POLBPDE3BPDE3A | |
| SCHEMBL30475505 | 0.81 | CRBN (0.48) | CRBNDDB1POLBPDE3BPDE3A | |
| SCHEMBL25035179 | 0.81 | CRBN (0.35) | CRBNDDB1IKZF3POLBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116322700-B | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-08-20 | — | — | CN | disclosed |
| CN-116322700-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-23 | — | — | CN | disclosed |