Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25031490 | 1.00 | GRM5 (0.37) | GRM5FFAR4ALDH1A1MAPTHPGD | |
| SCHEMBL29013187 | 0.93 | GRM5 (0.38) | GRM5FFAR4HRH3JAK3BRD4 | |
| SCHEMBL25935316 | 0.92 | FFAR4 (0.38) | FFAR4ALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL30479060 | 0.85 | FFAR4 (0.37) | GRM5FFAR4HRH3FEN1 | |
| SCHEMBL25939398 | 0.85 | FFAR4 (0.37) | GRM5FFAR4HRH3FEN1 | |
| SCHEMBL25938922 | 0.82 | LTA4H (0.41) | GRM5FFAR4CNR1PTGDR2PRMT5 | |
| SCHEMBL30136082 | 0.82 | LTA4H (0.41) | GRM5FFAR4CNR1PTGDR2PRMT5 | |
| SCHEMBL31018330 | 0.81 | FFAR4 (0.38) | GRM5FFAR4ALDH1A1MAPTCNR1 | |
| SCHEMBL25034787 | 0.81 | FFAR4 (0.40) | GRM5FFAR4CNR1NPY2R | |
| SCHEMBL30135909 | 0.81 | FFAR4 (0.40) | GRM5FFAR4CNR1NPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |