Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | HSD17B13 | Q7Z5P4 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31227425 | 0.77 | HPGD (0.43) | HSD17B13HPGDTSHRNPBWR1GRM2 | |
| SCHEMBL31227642 | 0.75 | GRM2 (0.44) | RORCHSD17B13CHRM5HPGDTSHR | |
| SCHEMBL31227110 | 0.71 | HSD17B13 (0.69) | HSD17B13 | |
| SCHEMBL31501594 | 0.70 | HSD17B13 (0.46) | HSD17B13HPGDTSHRNPBWR1 | |
| SCHEMBL31227482 | 0.69 | HSD17B13 (0.74) | HSD17B13 | |
| SCHEMBL30482284 | 0.67 | NPBWR1 (0.42) | HSD17B13HPGDTSHRNPBWR1MEN1 | |
| SCHEMBL26230068 | 0.67 | NPBWR1 (0.42) | HSD17B13HPGDTSHRNPBWR1MEN1 | |
| SCHEMBL10666397 | 0.65 | HPGD (0.49) | CYP3A4HPGDTSHRSCDMAOB | |
| SCHEMBL30482379 | 0.65 | HSD17B13 (0.39) | HSD17B13KIF11SCD | |
| SCHEMBL25431548 | 0.65 | HSD17B13 (0.51) | HSD17B13NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469451-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146897-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. (US) | 2023-08-03 | — | — | WO | disclosed |