Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B13 | Q7Z5P4 | 5/20 | 0.39 |
| ▸ | GNRHR | P30968 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | PARG | Q86W56 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30482281 | 0.81 | TDP1 (0.40) | HSD17B13GNRHRCMA1TDP1SCD | |
| SCHEMBL30482353 | 0.76 | GNRHR (0.43) | HSD17B13GNRHRCMA1TDP1PARG | |
| SCHEMBL31227182 | 0.74 | TSHR (0.41) | HSD17B13GNRHRCMA1TDP1PARG | |
| SCHEMBL26230397 | 0.70 | HSD17B13 (0.45) | HSD17B13GNRHRCMA1PARG | |
| SCHEMBL25433299 | 0.69 | HSD17B13 (0.74) | HSD17B13 | |
| SCHEMBL30482276 | 0.69 | HSD17B13 (0.74) | HSD17B13 | |
| SCHEMBL30482328 | 0.65 | RORC (0.40) | HSD17B13SCDKIF11 | |
| SCHEMBL30482352 | 0.62 | TSHR (0.55) | TDP1PARG | |
| SCHEMBL31333054 | 0.60 | ALDH1A1 (0.47) | TDP1SCDPLK1 | |
| SCHEMBL6256477 | 0.60 | MMP13 (0.41) | CMA1PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469451-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146897-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. (US) | 2023-08-03 | — | — | WO | disclosed |