Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PARG | Q86W56 | 2/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | C5AR1 | P21730 | 4/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24247609 | 0.81 | TSHR (0.59) | TSHRKDM4EHTTALDH1A1TDP1 | |
| SCHEMBL19555085 | 0.76 | MAPK8 (0.66) | PARGSLC9A1ERCC1FEN1ERCC4 | |
| SCHEMBL6363131 | 0.74 | MAPK8 (0.64) | TSHRKDM4ELMNAMAPK1HTT | |
| SCHEMBL24030794 | 0.73 | HDAC1 (0.73) | HTT | |
| SCHEMBL31227182 | 0.72 | TSHR (0.41) | TSHRKDM4ELMNAMAPK1HTT | |
| SCHEMBL30482353 | 0.72 | GNRHR (0.43) | TSHRKDM4ELMNAMAPK1HTT | |
| SCHEMBL17241596 | 0.72 | TSHR (0.62) | TSHRKDM4ELMNAALDH1A1TDP1 | |
| SCHEMBL6509732 | 0.72 | MEN1 (0.60) | TSHRSLC9A1MEN1KMT2AERCC1 | |
| SCHEMBL5039317 | 0.72 | ERCC1 (0.57) | TSHRKDM4ELMNAMAPK1HTT | |
| SCHEMBL11884498 | 0.72 | ERCC1 (0.62) | TSHRKDM4ELMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469451-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023146897-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. (US) | 2023-08-03 | — | — | WO | disclosed |