Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.43 |
| ▸ | PARG | Q86W56 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31227182 | 0.87 | TSHR (0.41) | GNRHRPARGTSHRALDH1A1NPC1 | |
| SCHEMBL26230397 | 0.78 | HSD17B13 (0.45) | GNRHRPARGLMNAHSD17B13CMA1 | |
| SCHEMBL30482332 | 0.76 | TDP1 (0.45) | GNRHRTDP1C5AR1 | |
| SCHEMBL30482379 | 0.76 | HSD17B13 (0.39) | GNRHRPARGTDP1HSD17B13CMA1 | |
| SCHEMBL30482352 | 0.72 | TSHR (0.55) | PARGTSHRALDH1A1NPC1KDM4E | |
| SCHEMBL25433299 | 0.72 | HSD17B13 (0.74) | HSD17B13 | |
| SCHEMBL30482276 | 0.72 | HSD17B13 (0.74) | HSD17B13 | |
| SCHEMBL31227425 | 0.70 | HPGD (0.43) | TSHRTDP1HSD17B13MEN1HPGD | |
| SCHEMBL31227306 | 0.65 | ADORA2A (0.45) | GNRHRALDH1A1KDM4ETDP1C5AR1 | |
| SCHEMBL31227314 | 0.65 | TDP1 (0.45) | GNRHRTDP1C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250100993-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2025-03-27 | — | — | US | disclosed |
| EP-4469451-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| CN-119032090-A | 2-Substituted thiazole HSD17B13 inhibitors and uses thereof | 伊尼制药公司 | 2024-11-26 | — | — | CN | disclosed |
| WO-2023146897-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250100993-A1 | 2-SUBSTITUTED THIAZOLE HSD17B13 INHIBITORS AND USES THEREOF | HSD17B1, HSD17B3, HSD17B13 | GNRHR 4149/4885PARG 4538/4885TSHR 2453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.