Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.81 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.77 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.73 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.70 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29485667 | 1.00 | HRH1 (0.81) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL29485634 | 1.00 | HRH1 (0.81) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL2845851 | 1.00 | HRH1 (0.81) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL725483 | 1.00 | HRH1 (0.81) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL8658187 | 1.00 | HRH1 (0.81) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL29485675 | 0.98 | TDP1 (0.80) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL724788 | 0.98 | TDP1 (0.80) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL12040598 | 0.94 | HRH1 (0.72) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL13098626 | 0.94 | HRH1 (0.72) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 | |
| SCHEMBL2843094 | 0.93 | CYP2A6 (0.76) | HRH1TDP1L3MBTL1CYP2A6TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9649301-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-9649301-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-9649301-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-05-16 | — | — | US | disclosed |
| US-9540327-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-01-10 | — | — | US | disclosed |
| US-9540327-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-01-10 | — | — | US | disclosed |
| US-9540327-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150352088-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150352088-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150352088-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2015-12-10 | — | — | US | disclosed |
| US-20140080859-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-8653275-B2 | Bis-quaternary ammonium cyclophane compounds that interact with neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-02-18 | — | — | US | disclosed |
| US-20100222377-A1 | BIS-QUATERNARY AMMONIUM CYCLOPHANE COMPOUNDS THAT INTERACT WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |
| US-20100222377-A1 | BIS-QUATERNARY AMMONIUM CYCLOPHANE COMPOUNDS THAT INTERACT WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |
| US-20100222377-A1 | BIS-QUATERNARY AMMONIUM CYCLOPHANE COMPOUNDS THAT INTERACT WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |
| US-20090318503-A1 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2009-12-24 | — | — | US | disclosed |
| US-20090318503-A1 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2009-12-24 | — | — | US | disclosed |
| US-20090318503-A1 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2009-12-24 | — | — | US | disclosed |
| WO-2007133614-A2 | BIS-QUATERNARY AMMONIUM CYCLOPHANE COMPOUNDS THAT INTERACT WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY (US) | 2007-11-22 | — | — | WO | disclosed |
| WO-2007094912-A2 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY (US) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007094912-A2 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY (US) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318503-A1 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA2, CHRNA5, CHRNA4 | HRH1 367/4885TDP1 1731/4885L3MBTL1 3428/4885 |
| US-20140080859-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | CHRNG, CHRNA10, CHRNA4 | HRH1 364/4885TDP1 1517/4885L3MBTL1 3853/4885 |
| US-20100222377-A1 | BIS-QUATERNARY AMMONIUM CYCLOPHANE COMPOUNDS THAT INTERACT WITH NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNG, CHRNA10, CHRNA4 | HRH1 364/4885TDP1 1517/4885L3MBTL1 3853/4885 |
| US-20150352088-A1 | Bis-Quaternary Ammonium Cyclophane Compounds that Interact with Neuronal Nicotinic Acetylcholine Receptors | CHRNG, CHRNA10, CHRNA4 | HRH1 364/4885TDP1 1517/4885L3MBTL1 3853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.