Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | RORC | P51449 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | FOS | P01100 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694246 | 1.00 | THRB (0.58) | THRBRORCALOX15ALOX12NPC1 | |
| SCHEMBL16953889 | 0.85 | THRB (0.48) | THRBRORCALOX15ALOX12NPC1 | |
| SCHEMBL30842447 | 0.85 | THRB (0.48) | THRBRORCALOX15ALOX12NPC1 | |
| SCHEMBL10239569 | 0.83 | THRB (0.46) | THRBRORCALOX15ALOX12POLB | |
| SCHEMBL28978485 | 0.83 | THRB (0.44) | THRBRORCALOX15ALOX12NPC1 | |
| Ammonia Solution, Strong SCHEMBL11077793 | 0.81 | THRB (0.44) | THRBRORCALOX15ALOX12POLB | |
| SCHEMBL12370100 | 0.81 | THRB (0.44) | THRBRORCALOX15ALOX12POLB | |
| SCHEMBL6690387 | 0.81 | THRB (0.44) | THRBRORCALOX15ALOX12POLB | |
| SCHEMBL12120763 | 0.81 | ALOX15 (0.50) | THRBRORCALOX15ALOX12GABRA1 | |
| SCHEMBL11082043 | 0.81 | TTR (0.50) | THRBRORCALOX15ALOX12POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023069700-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |