Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | NAAA | Q02083 | 1/20 | 0.61 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404789 | 0.97 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL4999081 | 0.91 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL1876940 | 0.86 | RECQL (0.72) | ALDH1A1SMN1; SMN2MAPTLMNAHPGD | |
| SCHEMBL9556986 | 0.84 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL2384676 | 0.84 | RECQL (0.70) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL15611152 | 0.82 | MAPT (0.90) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL10666712 | 0.80 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL4994038 | 0.80 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL15987432 | 0.80 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL6287119 | 0.79 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112142748-B | Pyrazolopyrimidine compound, and preparation method and application thereof | 上海医药集团股份有限公司 | 2023-07-04 | — | — | CN | disclosed |