Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.43 |
| ▸ | HTR2A | P28223 | 10/20 | 0.43 |
| ▸ | HTR2C | P28335 | 10/20 | 0.43 |
| ▸ | HTR2B | P41595 | 10/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312002 | 0.74 | SIGMAR1 (0.50) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL25345704 | 0.73 | CYP3A4 (0.49) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL25270662 | 0.72 | SIGMAR1 (0.54) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL8912704 | 0.71 | SIGMAR1 (0.54) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL25345710 | 0.71 | SIGMAR1 (0.47) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL27457057 | 0.71 | SIGMAR1 (0.73) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL8916017 | 0.71 | HTR2A (0.52) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL23023988 | 0.69 | HTR2A (0.43) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL23023989 | 0.69 | HTR2A (0.43) | SIGMAR1HTR2AHTR2CHTR2BADRA1D | |
| SCHEMBL8674607 | 0.69 | CRBN (0.53) | SIGMAR1HTR2AHTR2CHTR2BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448526-A1 | PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS | GENZYME CORPORATION (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114954-A1 | PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS | GENZYME CORPORATION (US) | 2023-06-22 | — | — | WO | disclosed |