Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.64 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059224 | 0.88 | AKR1C3 (0.65) | AKR1C3PKMPDE4BSMN1; SMN2CYP3A4 | |
| SCHEMBL3058872 | 0.88 | AKR1C3 (0.65) | AKR1C3PKMPDE4BSMN1; SMN2CYP3A4 | |
| SCHEMBL3062438 | 0.87 | AKR1C3 (0.59) | AKR1C3PKMPDE4BAKR1C1SMN1; SMN2 | |
| SCHEMBL3058949 | 0.84 | AKR1C3 (0.60) | AKR1C3PKMPDE4BSMN1; SMN2CYP3A4 | |
| SCHEMBL3059177 | 0.84 | AKR1C3 (0.60) | AKR1C3PKMPDE4BAKR1C1SMN1; SMN2 | |
| SCHEMBL3056631 | 0.83 | AKR1C3 (0.58) | AKR1C3PKMPDE4BSMN1; SMN2CYP3A4 | |
| SCHEMBL3061348 | 0.82 | PKM (0.84) | AKR1C3PKMPDE4BSMN1; SMN2CYP3A4 | |
| SCHEMBL3056417 | 0.82 | AKR1C3 (0.60) | AKR1C3PKMPDE4BAKR1C1SMN1; SMN2 | |
| SCHEMBL3062599 | 0.80 | CA7 (0.56) | AKR1C3PKMPDE4BSMN1; SMN2CYP3A4 | |
| SCHEMBL3051277 | 0.80 | MMP2 (0.46) | AKR1C3PDE4BCYP3A4NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | claimed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
| EP-2155192-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | Sterix Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | AKR1C3 1870/4885PKM 3021/4885PDE4B 1822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.