Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157734 | 0.90 | ALDH1A1 (0.44) | STSALDH1A1SMN1; SMN2NPSR1TP53 | |
| SCHEMBL23747269 | 0.88 | STS (0.36) | STSDDB1CRBNALDH1A1SMN1; SMN2 | |
| SCHEMBL20141452 | 0.86 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2NPSR1LMNADPP4 | |
| SCHEMBL20158218 | 0.80 | STS (0.42) | STSALDH1A1SMN1; SMN2NPSR1NR1H2 | |
| SCHEMBL20157752 | 0.79 | STS (0.44) | STSALDH1A1SMN1; SMN2NPSR1TP53 | |
| SCHEMBL30487540 | 0.77 | STS (0.35) | STSALDH1A1SMN1; SMN2NPSR1TP53 | |
| SCHEMBL21314409 | 0.74 | SMN1; SMN2 (0.33) | ALDH1A1SMN1; SMN2NPSR1LMNAGAA | |
| SCHEMBL21317536 | 0.74 | STS (0.50) | STSALDH1A1SMN1; SMN2NPSR1TP53 | |
| SCHEMBL20157732 | 0.72 | STS (0.39) | STSALDH1A1SMN1; SMN2NPSR1TP53 | |
| SCHEMBL21564441 | 0.68 | NR1H2 (0.43) | SMN1; SMN2NR1H2NAMPTDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | ITGB1, ITGB2, ITGA1 | STS 1072/4885DDB1 4119/4885CRBN 1028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.