Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 9/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3048813 | 1.00 | FKBP1A (0.50) | FKBP1AKLK7EPHX2MMP1MMP3 | |
| SCHEMBL8998403 | 0.89 | KLK7 (0.49) | FKBP1AKLK7KLK5 | |
| SCHEMBL8998386 | 0.89 | KLK7 (0.49) | FKBP1AKLK7KLK5 | |
| SCHEMBL8998390 | 0.89 | KLK7 (0.49) | FKBP1AKLK7KLK5 | |
| SCHEMBL25339275 | 0.86 | KLK7 (0.50) | KLK7KLK5 | |
| SCHEMBL30057132 | 0.86 | KLK7 (0.50) | KLK7KLK5 | |
| SCHEMBL28387244 | 0.86 | KLK7 (0.50) | KLK7KLK5 | |
| SCHEMBL6535959 | 0.86 | KLK7 (0.50) | KLK7KLK5 | |
| SCHEMBL25339274 | 0.86 | KLK7 (0.50) | KLK7KLK5 | |
| SCHEMBL5833831 | 0.85 | KLK7 (0.47) | FKBP1AKLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261914-A1 | IAP BINDING COMPOUNDS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2010-10-14 | — | — | US | disclosed |
| US-7718600-B2 | IAP binding compounds | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| EP-1578777-B1 | IAP BINDING COMPOUNDS | UNIV PRINCETON (US) | 2008-11-26 | — | — | EP | disclosed |
| US-20070032437-A1 | that bind cellular inhibitor of apoptosis proteins; drug design and development for diagnosis, prevention and treatment of cell proliferative disease; anticarcinogenic agents | THE TRUSTEES OF PRINCETON UNIVERSITY | 2007-02-08 | — | — | US | disclosed |
| EP-1578777-A4 | IAP BINDING COMPOUNDS | UNIV PRINCETON (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1578777-A2 | IAP BINDING COMPOUNDS | The Trustees of Princeton University (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004007529-A2 | IAP BINDING COMPOUNDS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032437-A1 | that bind cellular inhibitor of apoptosis proteins; drug design and development for diagnosis, prevention and treatment of cell proliferative disease; anticarcinogenic agents | BIRC3, API5, BID | FKBP1A 1553/4885KLK7 4561/4885EPHX2 4706/4885 |
| US-20100261914-A1 | IAP BINDING COMPOUNDS | BIRC3, BIRC5, BIRC2 | FKBP1A 1454/4885KLK7 4439/4885EPHX2 4365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.