Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8998386 | 1.00 | KLK7 (0.49) | KLK7PREPL3MBTL1MEN1KMT2A | |
| SCHEMBL8998390 | 1.00 | KLK7 (0.49) | KLK7PREPL3MBTL1MEN1KMT2A | |
| SCHEMBL3048816 | 0.89 | FKBP1A (0.50) | KLK7KLK5FKBP1A | |
| SCHEMBL3048813 | 0.89 | FKBP1A (0.50) | KLK7KLK5FKBP1A | |
| SCHEMBL25339274 | 0.84 | KLK7 (0.50) | KLK7PREPL3MBTL1MEN1KMT2A | |
| SCHEMBL30057132 | 0.84 | KLK7 (0.50) | KLK7PREPL3MBTL1MEN1KMT2A | |
| SCHEMBL6535959 | 0.84 | KLK7 (0.50) | KLK7PREPL3MBTL1MEN1KMT2A | |
| SCHEMBL25339275 | 0.84 | KLK7 (0.50) | KLK7PREPL3MBTL1MEN1KMT2A | |
| SCHEMBL28387244 | 0.84 | KLK7 (0.50) | KLK7PREPL3MBTL1MEN1KMT2A | |
| SCHEMBL20713742 | 0.82 | KLK7 (0.56) | KLK7PREPL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536737-A | Compound having prolyl endopeptidase inhibitory activity and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 1996-07-16 | — | — | US | disclosed |
| EP-0670309-A1 | COMPOUND WITH PROLYL ENDOPEPTIDASE INHIBITOR ACTIVITY AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 1995-09-06 | — | — | EP | disclosed |